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Target intelligence / Profile preview
Multiple Plasmodium Proteins (Artesunate Target) (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, DNA Replication Protein, Protease, Antioxidant Enzyme, Other
01
Overview
Artesunate acts by generating free radicals within Plasmodium parasites. These free radicals cause oxidative stress, damaging multiple essential proteins involved in DNA replication/repair (e.g., PfRFC1), hemoglobin degradation (e.g., falcipain 2), and antioxidant defense (e.g., SODs). This multi-targeted approach disrupts critical cellular processes and ultimately leads to parasite death.
- Other names
- Plasmodium proteinsArtesunate targetMalaria parasite proteinsPfRFC1, falcipain 2, SODs
02
Mechanism of action
Free radical generation leading to oxidative damage of multiple proteins
03
Biological functions
DNA replicationDNA repairProtein degradationHemoglobin degradationRedox homeostasisAntioxidant defense
04
Disease associations
Infection
05
Safety considerations
Potential for drug resistanceToxicity to host cells at high concentrations
06
Interacting drugs
Artesunate
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