Mus musculus microRNA 6361 (mmu-miR-6361) (mmu-miR-6361)

Mus musculus microRNA 6361 (mmu-miR-6361) is a small non-coding RNA molecule that functions as a post-transcriptional regulator of gene expression in mice [2]. It is primarily recognized for its role in modulating brain energy metabolism, specifically through the regulation of ATP levels in brain tissues [1]. Studies have linked mmu-miR-6361 to the pathology of Alzheimer's disease, where it interacts with long non-coding RNAs like lncRNA-9969 to influence neuroinflammation and neuronal autophagy [1]. By targeting specific messenger RNAs, it can modulate microglial activity and protect against metabolic disturbances associated with neurodegeneration [1]. Experimental tools such as mmu-miR-6361 mimics and inhibitors are utilized in research to study its functional impact and potential as a therapeutic target [5]. The therapeutic application of this microRNA involves the use of synthetic oligonucleotides to either enhance or suppress its activity, aiming to restore metabolic homeostasis in the brain [5], [9]. However, challenges such as off-target effects and efficient delivery across the blood-brain barrier remain significant hurdles for clinical development [16].

Other names

Mir6361mmu-mir-6361microRNA 6361

mmu-miR-6361 mimics supplement endogenous microRNA levels to enhance the silencing of target mRNAs, while inhibitors (antagomirs) bind to the mature microRNA to prevent its interaction with target transcripts, thereby restoring the expression of regulated genes [5], [9].