Muscarinic Acetylcholine Receptor (non-selective) (None)

Muscarinic acetylcholine receptors (mAChRs) are a family of G protein-coupled receptors that mediate the effects of the neurotransmitter acetylcholine. There are five known subtypes: M1, M2, M3, M4, and M5. A non-selective muscarinic receptor ligand interacts with all these subtypes. mAChRs play critical roles in mediating parasympathetic nervous system responses. Drugs targeting mAChRs include both selective and non-selective agents. Non-selective antagonists can cause broad anticholinergic effects due to their lack of subtype selectivity.

Other names

mAChR (non-selective)Muscarinic Receptor (non-selective)Non-selective Muscarinic Acetylcholine Receptor

Agonists like acetylcholine or muscarine bind to the receptor, inducing a conformational change that activates intracellular G proteins and downstream signaling cascades. Antagonists like atropine block endogenous ligand binding, preventing receptor activation.