MYCN opposite strand (protein and non-coding RNA forms) (MYCNOS)

MYCN opposite strand (MYCNOS, also known as NCYM) is a gene located antisense to the MYCN oncogene on chromosome 2, producing both a long non-coding RNA and—specifically in humans and chimpanzees—a small protein-coding transcript. This molecule functions both as a direct modulator of MYCN transcription (via promoter regulation and recruitment of protein complexes, including G3BP1) and as a contributor to pathological processes in cancer by stabilizing MYCN protein via inhibition of GSK3β-mediated degradation. MYCNOS antagonizes differentiation and apoptosis, promotes cell proliferation, and is co-amplified with MYCN in aggressive tumors such as neuroblastoma and retinoblastoma. It is notable for engaging in feedback loops with vital pluripotency regulators like OCT4 and MYCN, further supporting oncogenic progression and stemness. No drugs are currently known to target MYCNOS directly, but its central role in MYCN pathway dysregulation makes it an emerging consideration in pediatric oncology research[1][2][3][4].

Other names

N-cym proteinCYMNNCYMN-CYMMYCN-AS1N-myc opposite strandMYCN antisense RNA 1DNA-binding transcriptional activator NCYMMYCN opposite strand/antisense RNA (non-protein coding)v-myc myelocytomatosis viral related oncogene, neuroblastoma derived opposite strand

Epigenetic modulation of the MYCN promoter via protein recruitment (e.g., G3BP1)[1][2]; Direct regulation of MYCN transcriptional isoforms[1][2]; Inhibition of GSK3β-mediated proteolysis of MYCN, stabilizing the MYCN protein and promoting oncogenesis[3]; Scaffold for chromatin-modifying complexes (possible)[2]