Target intelligence / Profile preview

Mycobacterium tuberculosis Antigen (including ESAT-6 and CFP10) (None)

Target: None
Molecular classification: Protein antigen, Secreted protein

Overview

Mycobacterium tuberculosis antigens, including ESAT-6 and CFP10, are proteins produced by the bacterium that can be recognized by the host immune system. ESAT-6 and CFP10 are secreted proteins that play a role in virulence, immune modulation, and pathogenesis. They are strong T-cell stimulators and are highly specific for M. tuberculosis infection. Their presence forms the basis for several modern diagnostic tests for active or latent TB infection.

Other names: ESAT-6Early Secreted Antigenic Target 6 kDaCFP10Culture Filtrate Protein 10 kDaRv3875 (ESAT-6)Rv3874 (CFP10)

Mechanism of action

N/A

Biological functions

Immune stimulationT-cell activationVirulence factorImmune modulationApoptosis inductionInhibition of antigen presentationPhagosome disruption

Disease associations

TuberculosisMycobacterial infections

Biomarkers

Diagnostic marker for active and latent TB infection

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