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Myosin Binding Protein C, Cardiac (MYBPC3)
- Target
- MYBPC3
- Molecular classification
- Sarcomeric protein, Structural protein
01
Overview
The MYBPC3 gene encodes the cardiac isoform of myosin-binding protein C (cMyBP-C), a thick-filament associated protein found exclusively in heart muscle cells. cMyBP-C is a crucial component of the sarcomere—the fundamental contractile unit of striated muscle—where it plays both structural and regulatory roles. Loss or dysfunction of cMyBP-C leads to severe disruption in heart structure and function, including hypertrophy, disarrayed myocytes, increased calcium sensitivity, fibrosis, and impaired systolic/diastolic performance.
- Other names
- C-protein, cardiac muscle isoformMYBP-Cmyosin-binding protein C, cardiac-typeMYPC3_HUMAN
02
Mechanism of action
Modulation of sarcomere structure and function
03
Biological functions
Sarcomere stabilizationRegulation of cardiac muscle contractionSignaling node for sarcomeric structure maintenanceRegulation of contraction/relaxation cycles
04
Disease associations
Hypertrophic Cardiomyopathy (HCM)Dilated Cardiomyopathy (DCM)Left Ventricular Noncompaction
05
Safety considerations
ArrhythmiaHeart FailureSudden Death
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