Myosin light chain 1, skeletal muscle isoform (MYL1)

Myosin light chain 1, skeletal muscle isoform (MYL1) is a non-regulatory “essential” (alkali) light chain expressed predominantly in fast skeletal muscle[1][3][7]. It is part of the myosin hexameric complex: two heavy chains, two essential (alkali) light chains, and two regulatory light chains[1][3][4]. MYL1 binds to the IQ1 motif on the myosin heavy chain neck region, stabilizing the structure and contributing to muscle contraction by modulating the ATPase activity of the entire complex[4][6]. MYL1 is necessary for proper muscle fiber formation and maintenance[1][7]; defects in MYL1 can lead to congenital myopathies characterized by muscle weakness and structural abnormalities[1][5]. As a member of the EF-hand family, it contains calcium-binding motifs but is classified as non-regulatory, with its function focused on structural integrity and modulation of force rather than direct signal transduction[4][6]. There are no drugs that specifically target MYL1, and it is not considered a conventional therapeutic target like a receptor or enzyme[1][4][7].

Other names

Myosin light chain 1/3, skeletal muscle isoformMLC1MLC3MLC1FMLC3FMyosin light chain A1/A2MLC-1MLC1/3Myosin light chain alkali 1/2CMYO14CMYP14MYOFTAmyosin, light chain 1, alkaliskeletal, fastmyosin, light polypeptide 1, alkali