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Target intelligence / Profile preview
Myosin regulatory light chain 2, atrial isoform (MYL7)
- Target
- MYL7
- Molecular classification
- Other, Motor protein (regulatory light chain of myosin)
01
Overview
Myosin regulatory light chain 2, atrial isoform (MYL7) is a regulatory light chain subunit of the myosin motor complex specifically enriched in atrial cardiac muscle. It enables calcium ion binding, is essential for cardiac muscle contractility, and participates in development and maintenance of cardiac myofibril structure. Mutations or dysregulation of MYL7 are implicated in congenital cardiovascular diseases such as hypoplastic left heart syndrome and heart septal defects[2][5][7].
- Other names
- MYL7MYL2AMYLC2AMLC-2aMLC2aMyosin light chain 2amyosin, light polypeptide 7, regulatoryRLC-AMlc20MLC-2alpha
02
Biological functions
Cardiac muscle tissue developmentHeart contractionMyofibril assemblyCalcium ion bindingCytoskeleton remodeling
03
Disease associations
Cardiovascular disease (notably, congenital heart diseases such as hypoplastic left heart syndrome and heart septal defect)
04
Biomarkers
Potential biomarker for cardiac muscle development and disease
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