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N-alpha-acetyltransferase 25, NatB auxiliary subunit (NAA25)
- Target
- NAA25
- Molecular classification
- Enzyme auxiliary subunit, Protein complex subunit (NatB complex), Other (non-catalytic component)
01
Overview
N-alpha-acetyltransferase 25, NatB auxiliary subunit (NAA25) is the non-catalytic, auxiliary component of the N-terminal acetyltransferase B (NatB) protein complex. The NatB complex acetylates the N-terminal methionine of proteins that are immediately followed by acidic or asparagine/glutamine residues (Met-Asp, Met-Glu, Met-Asn, Met-Gln). NAA25 does not possess catalytic activity but is essential for complex stability and function, and it may play a role in normal cell cycle progression. Mutations in NAA25 are associated with disorders such as high pressure neurological syndrome and microphthalmia, syndromic 1. No direct drugs or inhibitors are currently known to target this protein[1][3][4][5][6].
- Other names
- C12orf30MDM20NAP1FLJ13089NatB complex subunit MDM20Mitochondrial distribution and morphology protein 20N-terminal acetyltransferase B complex subunit MDM20N-terminal acetyltransferase B complex subunit NAA25p120N(α)-acetyltransferase 25, NatB auxiliary subunit4833422K13RikA630046C11AI450868C330023M02RikLRRGT00164RGD1305685[1][2]
02
Mechanism of action
Not applicable (no known direct drug interactions; NAA25 functions as an auxiliary, non-catalytic subunit)[1][3][6]
03
Biological functions
N-terminal acetylation of proteins (as part of NatB complex)Cell cycle progression
04
Disease associations
High pressure neurological syndromeMicrophthalmia, syndromic 1[1]Other (no strong direct links to major therapeutic disease targets documented)
05
Safety considerations
Potential impact on cell cycle progression if NatB complex is inhibited[5]Unknown in a therapeutic context (no drugs or inhibitors in current clinical use)
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