N-alpha-acetyltransferase 30, NatC catalytic subunit (NAA30)

N-alpha-acetyltransferase 30 (NAA30) is the catalytic subunit of the NatC N-terminal acetyltransferase complex, an enzyme that co-translationally acetylates the N-termini of numerous eukaryotic proteins (especially those beginning with methionine followed by hydrophobic or amphipathic residues). NAA30’s activity stabilizes substrate proteins, protects them from degradation, and is required for correct mitochondrial function, organelle targeting, and cell viability. Loss or overexpression of NAA30 influences cancer cell growth and survival, and genetic variants are implicated in developmental syndromes and mitochondrial disease. NatC complexes are evolutionarily conserved and crucial for acetylating specific protein subsets across eukaryotes.

Other names

C14orf35MAK3NAT12FLJ35355Mak3pN-acetyltransferase 12N-acetyltransferase MAK3 homologNAT12PN-terminal acetyltransferase CNatC catalytic subunit

Inhibition of protein N-terminal acetylation, which has the potential to disrupt mitochondrial function, cell proliferation, and cancer cell viability by interfering with acetylation of substrate proteins, leading to increased protein degradation and altered organelle function.