N-alpha-acetyltransferase 40, NatD catalytic subunit (NAA40)

N-alpha-acetyltransferase 40 (NAA40, also called NatD catalytic subunit) is a protein acetyltransferase enzyme that specifically catalyzes N-terminal acetylation of histones H4 and H2A, thus regulating chromatin structure and gene expression[1][3][6]. Unlike other N-terminal acetyltransferases, NAA40 shows high substrate specificity, targeting the Ser-Gly-Arg-Gly N-terminus of H4 and H2A. NAA40 is localized primarily in the nucleoplasm and cytosol and is involved in chromatin remodeling, developmental regulation, and the suppression of apoptosis. Genetic and functional studies in human and model organisms indicate key roles in developmental transitions and potential contributions to diseases such as cancer and rare congenital anomalies[1][2][5][6].

Other names

PATT1hNatDNatDNAT11FLJ13848N-acetyltransferase 11N-alpha-acetyltransferase Dprotein acetyltransferase 1EC 2.3.1.257N(alpha)-acetyltransferase 40 (NatD) catalytic subunit homologN-alpha acetyl transferase 40NAA40_HUMANNatD catalytic subunit

Inhibitors would potentially block N-terminal acetylation of target histones, altering chromatin states and gene expression