Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
N-methyl-D-aspartate Receptor (GluN2B Subunit) (GluN2B)
- Target
- GluN2B
- Molecular classification
- Ion channel, Receptor, Glutamate receptor, NMDA receptor
01
Overview
The N-methyl-D-aspartate receptor (NMDA receptor, or NMDAR) is a type of ionotropic glutamate receptor that plays a central role in excitatory neurotransmission, synaptic plasticity, learning, and memory in the central nervous system. The GluN2B subunit is one of the regulatory subunits that combine with two obligatory GluN1 subunits to form functional NMDA receptors. GluN2B-containing NMDARs are considered promising therapeutic targets due to their involvement in neurodevelopmental disorders, neurodegeneration, chronic pain syndromes, depression/anxiety disorders—and because selective antagonism may offer clinical benefits with fewer side effects compared to non-selective blockade.
- Other names
- NR2BNMDA receptor subunit 2BGlutamate [NMDA] receptor subunit epsilon-2HNR3GluN2B
02
Mechanism of action
Agonist binding, ion channel modulation (blockade/potentiation)
03
Biological functions
Synapse developmentSynaptic plasticityLearningMemoryExcitatory neurotransmission
04
Disease associations
Alzheimer’s diseaseHuntington’s diseaseParkinson’s diseaseNeurodegenerative diseaseNeurodevelopmental disordersChronic pain syndromesDepressionAnxiety disordersCognitive impairment
05
Safety considerations
ExcitotoxicityExcessive Ca²⁺ influxPotential for side effects with non-selective blockade
06
Interacting drugs
Glutamate
5 more in the full profile.
Beyond the preview
Go deeper on N-methyl-D-aspartate Receptor (GluN2B Subunit) (GluN2B).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on N-methyl-D-aspartate Receptor (GluN2B Subunit) (GluN2B).