Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
N-methyl-D-aspartate receptor (NMDA) - Glycine Site (None)
- Target
- None
- Molecular classification
- Ionotropic glutamate receptor, Receptor
01
Overview
The glycine site on the NMDA receptor is a binding domain on the GluN1 subunit that is essential for receptor activation. Glycine or D-serine must bind to this site simultaneously with glutamate binding to the GluN2 subunit for the ion channel to open. The NMDA receptor plays a critical role in synaptic plasticity, learning, memory, and neurodevelopment. Dysfunction of the glycine site has been implicated in several neurological disorders.
02
Mechanism of action
Agonist or antagonist binding to the glycine site on the NMDA receptor modulates channel activity.
03
Biological functions
Synaptic plasticityLearningMemory formationNeurodevelopmentExcitatory neurotransmission
04
Disease associations
SchizophreniaAlzheimer’s diseaseParkinson’s diseaseIschemic stroke-related damageEpilepsyChronic pain syndromesNeurodegenerative diseaseExcitotoxicity
05
Safety considerations
ExcitotoxicityPotential for off-target effects due to widespread NMDA receptor distribution
06
Interacting drugs
Glycine
3 more in the full profile.
Beyond the preview
Go deeper on N-methyl-D-aspartate receptor (NMDA) - Glycine Site (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on N-methyl-D-aspartate receptor (NMDA) - Glycine Site (None).