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Target intelligence / Profile preview
NAD(P)H dehydrogenase [quinone] 2 (QR2)
- Target
- QR2
- Molecular classification
- Enzyme, Flavoprotein
01
Overview
NAD(P)H dehydrogenase [quinone] 2 (QR2), also known as NQO2, is an enzyme involved in cellular detoxification. While originally classified as the MT3 melatonin receptor due to its affinity for certain melatonergic ligands, it primarily functions as a quinone reductase. It catalyzes the two- or four-electron reduction of quinones, contributing to cellular defense against oxidative stress. QR2 is a homodimeric flavoprotein containing FAD cofactors and zinc ions.
- Other names
- NQO2Quinone Reductase 2MT3 receptorNAD(P)H dehydrogenase, quinone 2
02
Mechanism of action
Reduces quinones via a ping-pong mechanism involving hydride transfer from reduced dihydronicotinamide riboside (NRH) to FAD, followed by reduction of the quinone substrate.
03
Biological functions
DetoxificationRedox homeostasisQuinone reduction
04
Disease associations
CancerOxidative stress-related diseases
05
Interacting drugs
Resveratrol
2 more in the full profile.
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