Target intelligence / Profile preview

NAD+ kinase (NADK)

Target: NADK
Molecular classification: Enzyme, Kinase

Overview

NADP+ synthesis refers to the enzymatic process by which NAD+ is phosphorylated to NADP+ via NAD+ kinase (NADK). NADP+ is an essential electron carrier and cofactor in numerous anabolic reactions, and its reduced form, NADPH, is crucial for biosynthesis and protection against oxidative stress. NADK activity is ubiquitous in prokaryotic and eukaryotic cells, and regulation of NADP+ levels is tightly linked to cellular metabolism, stress response, and disease[2][5].

Other names: NAD+ kinaseNAD kinaseNADK

Biological functions

NADP+ biosynthesis (catalyzes phosphorylation of NAD+ to produce NADP+)[2][5]Regulation of redox balance in cellsSupports pathways requiring NADPH for anabolic reactions and antioxidant defense

Disease associations

Cancer (altered NADP+/NADPH ratio implicated in cell proliferation and oxidative stress response)[2]Metabolic disease (altered NADP+ metabolism in diabetes, obesity, aging)[2]Other (as a fundamental player in redox homeostasis, may be involved in various pathologic states)

Beyond the preview

Go deeper on NAD+ kinase (NADK).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on NAD+ kinase (NADK).

Explore the full profile