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Target intelligence / Profile preview
NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5)
- Target
- SIRT5
- Molecular classification
- Enzyme, Sirtuin, Protein deacylase, Mono-ADP-ribosyltransferase
01
Overview
SIRT5 is an NAD+-dependent protein lysine deacylase primarily localized in the mitochondrial matrix. It regulates various metabolic processes by removing succinyl, malonyl, and glutaryl groups from lysine residues on target proteins. It plays a role in glycolysis, the TCA cycle, fatty acid oxidation, the electron transport chain, ketone body formation, the urea cycle, nitrogenous waste management, and ROS detoxification. It is considered a potential drug target for treating metabolic disorders, cardiovascular diseases, cancer, and neurodegeneration.
- Other names
- Sirtuin 5Sir2-related NAD+-dependent protein deacylase sirtuin‑5
02
Mechanism of action
Inhibition or activation of SIRT5 enzymatic activity (desuccinylation, demalonylation, deglutarylation)
03
Biological functions
Metabolic regulationDesuccinylationDemalonylationDeglutarylationUrea cycle regulationKetogenesis regulationROS detoxificationTCA cycle regulationFatty acid oxidation regulation
04
Disease associations
CancerCardiovascular diseaseNeurodegenerative diseaseMetabolic disorders
05
Safety considerations
Context-dependent tumor promoter or suppressor activityOff-target effects due to NAD+ binding
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