NADH:Ubiquinone Oxidoreductase Core Subunit V1 (NDUFV1)

The NADH:Ubiquinone Oxidoreductase Core Subunit V1 (NDUFV1) is a component of the mitochondrial NADH dehydrogenase complex I, crucial for electron transport and oxidative phosphorylation. It contains sites for NADH binding, flavin mononucleotide, and iron-sulfur clusters, facilitating the transfer of electrons from NADH to ubiquinone while pumping protons across the inner mitochondrial membrane. This process is vital for ATP synthesis. Defects in complex I, including those involving NDUFV1, are linked to mitochondrial disorders and neurodegenerative diseases[1][2][3].

Other names

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNDUV1UQOR1CI-51kDCI-51KComplex I-51kDNADH dehydrogenase (ubiquinone) flavoprotein 1NADH-ubiquinone oxidoreductase 51 kDa subunitComplex I 51 kDa subunit

Electron transfer from NADH to ubiquinone, proton translocation across the inner mitochondrial membrane