NADH:Ubiquinone Oxidoreductase Subunit A10 mRNA 3'-untranslated region (NDUFA10 mRNA 3'-UTR)

The NDUFA10 mRNA 3'-untranslated region (3'-UTR) is a critical regulatory segment of the messenger RNA encoding the NADH:Ubiquinone Oxidoreductase Subunit A10, an accessory subunit of mitochondrial Complex I (UniProt O95299). This region contains specific motifs, such as microRNA binding sites (notably for miR-1825) and sequence-specific RNA-binding elements (SREs), which govern the stability and translational efficiency of the NDUFA10 transcript (Pandey et al., 2017). In Oculopharyngeal Muscular Dystrophy (OPMD), mutations in the poly(A) binding protein nuclear 1 (PABPN1) lead to defective polyadenylation and accelerated decay of NDUFA10 mRNA, contributing to mitochondrial dysfunction and muscle pathology (Chartier et al., 2015). Furthermore, the NDUFA10 3'-UTR is a target for miR-1825, which has been shown to repress NDUFA10 expression and inhibit cardiomyocyte proliferation, making it a potential target for heart regeneration therapies. As NDUFA10 is essential for the assembly and activity of the electron transport chain, its regulation via the 3'-UTR is vital for maintaining cellular energy homeostasis and is a focal point for developing RNA-targeted therapeutics in metabolic and degenerative diseases (Janssen et al., 2011). Dysregulation of this UTR is also implicated in cancer and Alzheimer's disease, where altered NDUFA10 levels correlate with disease progression.

Other names

CI-42kD mRNA 3'-UTRComplex I-42kD mRNA 3'-UTRNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10 mRNA 3'-UTRNDUFA10 3'-untranslated region

The target is modulated through microRNA-mediated translational repression or mRNA destabilization. Therapeutic strategies involve using microRNA mimics or inhibitors to alter NDUFA10 protein expression, or antisense oligonucleotides to block regulatory elements in the 3'-UTR.