NADH:ubiquinone oxidoreductase subunit A7 (NDUFA7)

NADH:ubiquinone oxidoreductase subunit A7 (NDUFA7) is an accessory, non-catalytic subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase), the first and largest enzyme of the respiratory electron transport chain[1][6][7]. Located on the inner mitochondrial membrane, complex I drives electron transfer from NADH to ubiquinone, powering ATP production by creating a proton gradient. NDUFA7 is a small hydrophobic protein (12.5 kDa, 113 amino acids) that contributes structurally to the integrity and stability of the multiprotein complex but is not involved directly in electron transfer or catalysis[1][2][3]. Mutations or dysfunction of NDUFA7 and other complex I subunits can compromise mitochondrial respiration, resulting in a range of inherited or acquired disorders, including several types of anemia, neurodegenerative conditions, metabolic diseases, and various cancers[1][2]. While NDUFA7 is not typically considered a direct therapeutic target, its role is crucial for proper mitochondrial function and cellular energy homeostasis.

Other names

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7CI-B14.5aB14.5aComplex I-B14.5aNADH-ubiquinone oxidoreductase subunit B14.5acomplex I B14.5a subunitNDUFA7

Not targeted directly by drugs; complex I inhibitors act by blocking electron transport or ubiquinone reduction in the entire complex