NADH:ubiquinone oxidoreductase subunit S5 pseudogene 3 (NDUFS5P3)

NDUFS5P3 is a pseudogene corresponding to the NADH:ubiquinone oxidoreductase subunit S5 gene (NDUFS5). Pseudogenes are segments of DNA that resemble functional genes but do not encode active proteins. Consequently, NDUFS5P3 does not produce a functional protein and is not known to have a biological or disease-related function. It is not considered a therapeutic target, as it does not encode an active receptor, enzyme, transporter, or other druggable protein. NADH:ubiquinone oxidoreductase (Complex I) is a mitochondrial enzyme complex essential for cellular energy production and redox balance, with functional subunits such as NDUFS6 and NDUFS8 being crucial for its activity[1][3][5]. However, NDUFS5P3 is explicitly annotated as a pseudogene, meaning it is a non-functional copy and not a protein-coding gene[5]. Therefore, no mechanism of action, interacting drugs, disease associations, or biomarker status exists for NDUFS5P3. Additionally, it should not be confused with active subunits (such as NDUFS5, NDUFS6, or NDUFS8), which are legitimate components of Complex I and actual therapeutic or research targets[1][3][5].

Other names

NDUFS5P3NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 pseudogene 3