NADH:ubiquinone oxidoreductase subunit S5 pseudogene 4 (NDUFS5P4)

NADH:ubiquinone oxidoreductase subunit S5 pseudogene 4 (NDUFS5P4) is a human pseudogene, meaning it is a non-functional segment of DNA that resembles a gene but typically does not encode a functional protein[1]. It is classified as a processed pseudogene, related by sequence to the active NDUFS5 gene (NADH:ubiquinone oxidoreductase subunit S5), but is generally considered non-functional and does not contribute a protein product to mitochondrial complex I. While most pseudogenes are regarded as nonfunctional "genomic fossils," some have regulatory roles at the RNA level, such as acting as miRNA decoys or sources of small interfering RNAs, although there is no specific published evidence for such a function for NDUFS5P4 itself[1][4]. As a pseudogene, it is not considered a therapeutic target or involved in classic drug-target interactions. Key points: - NDUFS5P4 is a pseudogene, not a protein-coding gene or a classical drug target[1]. - Pseudogenes sometimes regulate the expression of their parental genes (e.g., through RNA-mediated mechanisms), but a functional role for NDUFS5P4 has not been established[4]. - No drugs, biomarkers, or disease roles are specifically attributed to NDUFS5P4. - The entry describes a pseudogene and is unlikely to be a relevant therapeutic target. If your intention was to refer to the functional protein-coding gene (NDUFS5, not NDUFS5P4), please clarify—the NDUFS5 gene encodes a protein subunit of mitochondrial complex I which has biologically important roles but is distinct from NDUFS5P4[1].

Other names

NDUFS5P4NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 pseudogene 4