NADH:ubiquinone oxidoreductase subunit S6 pseudogene 1 (NDUFS6P1)

NDUFS6P1 is a pseudogene derived from the functional NDUFS6 gene, which encodes a subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase)[1]. Pseudogenes are genomic sequences that resemble functional genes but contain gene-disabling mutations and lack the regulatory elements required for transcription or translation[2]. While some pseudogenes show developmental expression patterns and may have regulatory roles, NDUFS6P1 specifically appears to be a non-functional pseudogene copy of the NDUFS6 gene[2]. The parent gene NDUFS6 encodes a critical component of the mitochondrial electron transport chain, but the pseudogene version (NDUFS6P1) does not produce a functional protein[3][4]. Research has shown that some pseudogenes can be transcribed and may play regulatory roles during development, though their direct therapeutic relevance remains limited compared to their functional gene counterparts[2].

Other names

NDUFS6P1

None (pseudogenes do not encode functional proteins)