NADH dehydrogenase, quinone 2 pseudogene (null)

This entry refers to a pseudogene of NAD(P)H dehydrogenase, quinone 2 (NQO2), a cytosolic flavoprotein enzyme involved in quinone detoxification and cellular redox regulation. The functional NQO2 enzyme (encoded by the NQO2 gene) is a phase II detoxification enzyme that catalyzes the two- or four-electron reduction of quinones using dihydronicotinamide riboside as an electron donor, contributing to protection against oxidative stress and chemical toxicity[1][3]. However, the pseudogene form (ENSG00000274855) does not encode a functional protein, is not involved in these processes, and is not considered a therapeutic target. Context: - NQO2 (functional gene/protein, not the pseudogene) is implicated in breast cancer, agranulocytosis, neurodegenerative diseases, and can be inhibited by compounds like resveratrol[1][3]. However, none of these roles or drug interactions apply to the pseudogene ENSG00000274855. Summary for future extraction: - The pseudogene "NADH dehydrogenase, quinone 2 pseudogene" is not a valid drug target, does not encode an active enzyme, and has no established roles as a biomarker, disease gene, or therapeutic target[1][3]. Any therapeutic relevance applies to the nearby functional gene NQO2, not to this pseudogene.

Other names

NQO2PNQO2 pseudogeneNAD(P)H quinone dehydrogenase 2 pseudogene

null