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NADH dehydrogenase [ubiquinone]
- Molecular classification
- Enzyme, Oxidoreductase, Complex I
01
Overview
NADH dehydrogenase is a key enzyme in cellular respiration, specifically functioning as the first enzyme of the mitochondrial electron transport chain (Complex I). It catalyzes the oxidation of NADH to NAD+, transferring electrons from NADH to ubiquinone (coenzyme Q10), which is then reduced to ubiquinol. This process is coupled with proton translocation across the inner mitochondrial membrane, contributing to ATP synthesis via oxidative phosphorylation.
- Other names
- cytochrome c reductasetype 1 dehydrogenasebeta-NADH dehydrogenase dinucleotidediaphoraseDPNH diaphoraseNADH oxidoreductase
02
Mechanism of action
Inhibition of NADH oxidation and electron transfer to ubiquinone, disruption of proton gradient formation
03
Biological functions
Electron transportProton translocationOxidative phosphorylationEnergy productionSuperoxide production
04
Disease associations
Mitochondrial diseasesNeurodegenerative diseaseOther
05
Safety considerations
Impaired energy metabolismIncreased superoxide production
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