NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (NDUFA3)

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (NDUFA3) is a small accessory subunit of mitochondrial respiratory chain Complex I, localized to the inner mitochondrial membrane[1][6]. It contributes to assembly and structural integrity of Complex I, which is responsible for electron transfer from NADH to ubiquinone in oxidative phosphorylation. Although NDUFA3 itself is not believed to participate in catalytic electron transfer, its loss can impair mitochondrial function and is associated with mitochondrial diseases and some neurodegenerative disorders[1][2][3][4][6].

Other names

NDUFA3Complex I-B9CI-B9NADH-ubiquinone oxidoreductase B9 subunitcomplex I B9 subunitB9

Not a direct drug target; no drugs are known to modulate NDUFA3 specifically. Pathophysiological changes are due to effects on mitochondrial Complex I.