NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (NDUFB2)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (NDUFB2), is an accessory subunit of Complex I (NADH:ubiquinone oxidoreductase) in the mitochondrial respiratory chain. It does not participate directly in the catalytic activity of electron transfer but is important for complex stability and function. Complex I is responsible for the transfer of electrons from NADH to ubiquinone (coenzyme Q10), an essential step in oxidative phosphorylation and ATP production. NDUFB2 helps anchor the complex within the inner mitochondrial membrane and may play a role in modulating complex I assembly or stability. Alterations in NDUFB2 expression or function have been associated with several pathological conditions, including mitochondrial diseases (such as Leigh disease), oxidative stress in cardiac injury, and venous thromboembolism in the context of liver disease. Note: - No direct drugs are known to target NDUFB2 specifically; any interaction would be as part of general Complex I inhibitors (such as rotenone), but these are not clinically used due to toxicity. - NDUFB2 is considered a molecular target for research and may serve as a biomarker in certain oxidative and mitochondrial pathologies, but not a current direct therapeutic target.

Other names

CI-AGGGAGGGNDUB2NADH:ubiquinone oxidoreductase subunit B2complex I-AGGGNADH-ubiquinone oxidoreductase AGGG subunitNADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa