Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (NDUFB4)
- Target
- NDUFB4
- Molecular classification
- Enzyme accessory subunit (accessory subunit of mitochondrial NADH:ubiquinone oxidoreductase, Complex I), Mitochondrial electron transport chain protein
01
Overview
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (NDUFB4) is an accessory, non-catalytic subunit of mitochondrial Complex I, the first and largest enzyme in the electron transport chain. Complex I is crucial for cellular energy production, mediating the transfer of electrons from NADH to ubiquinone[1][2][6][7]. NDUFB4 contributes to the structure and assembly of the complex but does not participate directly in redox catalysis. Mutations or loss of function in NDUFB4 have been associated with mitochondrial disease, implicating it in the integrity and functionality of mitochondrial respiration[2][6]. There are currently no drugs or approved therapies that selectively target NDUFB4, nor is it used as a biomarker in clinical practice.
- Other names
- NDUFB4NADH:ubiquinone oxidoreductase subunit B4NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4Complex I-B15CI-B15NADH-ubiquinone oxidoreductase B15 subunitB15Complex I B15 subunitNADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
02
Biological functions
Electron transport: participates as a structural and accessory subunit in mitochondrial Complex I, which transfers electrons from NADH to ubiquinone during cellular respirationMitochondrial respiration: helps maintain the integrity and function of Complex I in the oxidative phosphorylation pathwayComplex assembly/biogenesis: may contribute to scaffolding and assembly of complex I
03
Disease associations
Mitochondrial disease: variants or loss of function are associated with mitochondrial disordersPolyomavirus-associated nephropathy: linked in gene-disease databasesOther possible associations via dysfunction of mitochondrial complex I (implied)
04
Safety considerations
Dysfunction could potentially result in impaired mitochondrial respiration and associated toxicity, but no specific safety issues or therapeutic challenges have been documented for targeting NDUFB4 directly
Beyond the preview
Go deeper on NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (NDUFB4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (NDUFB4).