NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (NDUFB6)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (NDUFB6) is an accessory, non-catalytic subunit of complex I (NADH:ubiquinone oxidoreductase) in the mitochondrial inner membrane. Although not directly involved in electron transfer catalysis, NDUFB6 is required for the proper assembly and stability of complex I, which initiates the electron transport chain by transferring electrons from NADH to ubiquinone, contributing to the proton gradient used for ATP synthesis. Genetic changes in NDUFB6 are linked to rare mitochondrial diseases, and changes in its expression level have been implicated in metabolic disorders such as type 2 diabetes, insulin resistance, and age-related muscle decline. The molecule is localized to the mitochondrial inner membrane and is essential for efficient aerobic respiration. Although it is not a direct drug target for current therapies, alterations may have biomarker relevance or contribute to mitochondrial dysfunction.

Other names

Complex I-B17CI-B17NADH-ubiquinone oxidoreductase B17 subunitB17 subunitNADH-ubiquinone oxidoreductase beta subunit 617 kDa proteinDD6C4-3DD6C4-4Gm137

No drugs directly characterized as targeting NDUFB6; NADH interacts as a substrate with the overall complex I; mechanism involves transfer of electrons from NADH to ubiquinone in the mitochondrial electron transport chain