NADH dehydrogenase [ubiquinone] 1 subunit C2 (NDUFC2)

NADH dehydrogenase [ubiquinone] 1 subunit C2 (NDUFC2) is a nuclear-encoded accessory subunit of mitochondrial complex I, the first and largest enzyme of the electron transport chain. NDUFC2 is essential for the assembly and activity of complex I, facilitating electron transfer from NADH to ubiquinone. Deficiency or decreased expression of NDUFC2 leads to mitochondrial dysfunction, increased oxidative stress, and impaired ATP synthesis. NDUFC2 dysfunction is implicated in the pathogenesis of several diseases including mitochondrial disorders, diabetes, cancer, and cardiovascular conditions such as stroke. Resveratrol, an antioxidant molecule, can counteract reactive oxygen species generation due to NDUFC2 deficiency, highlighting its relevance as a potential therapeutic target[1][2][3][5].

Other names

NDUFC2HLC-1B14.5bNADH-ubiquinone oxidoreductase subunit B14.5bHuman lung cancer oncogene 1 proteinNADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDaComplex I-B14.5bMC1DN36NADHDH2

Enhancement of mitochondrial function and reduction of ROS by antioxidants (e.g., resveratrol) Potential restoration of complex I activity