NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (NDUFS7)

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (NDUFS7), is a core subunit of Complex I of the mitochondrial respiratory chain, vital for electron transfer from NADH to ubiquinone, resulting in generation of a proton gradient used for ATP synthesis. It contains iron-sulfur clusters and is part of the catalytic core involved in electron transfer and proton translocation. Mutations in NDUFS7 cause mitochondrial complex I deficiency, especially Leigh syndrome—a severe neurodegenerative disorder—and other mitochondrial diseases. Dysfunction disrupts complex I assembly, increases oxidative stress, and impairs cellular respiration. NDUFS7 is not a direct therapeutic drug target but is of high clinical relevance in rare genetic and metabolic diseases.

Other names

NADH:ubiquinone oxidoreductase core subunit S7CI-20kDPSSTFLJ46880FLJ45860CI-20Complex I-20kDNADH-ubiquinone oxidoreductase 20 kDa subunitPSST subunitcomplex I 20kDa subunitNADH dehydrogenase (ubiquinone) Fe-S protein 720kDa (NADH-coenzyme Q reductase)MC1DN3MY017NADH:Ubiquinone Oxidoreductase Core Subunit S7NADH-Ubiquinone Oxidoreductase 20 KDa SubunitNADH Dehydrogenase (Ubiquinone) Fe-S Protein 7PSST SubunitComplex I 20kDa Subunit

Not applicable—no approved drugs directly targeting this subunit. Experimental modulation relates to complex I inhibition or mitochondrial function alteration, which generally affects electron transfer/proton translocation in NADH:ubiquinone oxidoreductase