Target intelligence / Profile preview

NADPH oxidase 1 (NOX1) (NOX1)

Target: NOX1
Molecular classification: Enzyme [5, 11], Oxidoreductase [5, 11], NADPH oxidase family [12, 16]

Overview

NADPH oxidase 1 (NOX1) is a transmembrane enzyme that belongs to the NADPH oxidase family, primarily functioning to generate reactive oxygen species (ROS) by transferring electrons from NADPH to molecular oxygen [5, 11]. It acts as the catalytic core of a multi-protein complex that includes regulatory subunits such}

Other names: Mitogenic oxidase 1 [5, 11]MOX1 [5, 11]NOH-1 [5, 11]NADPH oxidase homolog 1 [11]NADH/NADPH mitogenic oxidase subunit P65-MOX [5, 11]GP91-2 [5]

Mechanism of action

Inhibition of the catalytic activity of the NOX1 enzyme, thereby reducing the production of superoxide and other reactive oxygen species (ROS) [2, 3, 13].

Biological functions

Reactive oxygen species production [5, 11]Cell signaling [13, 18]Cell proliferation [20]Host defense [11, 20]Angiogenesis [18, 20]Blood pressure regulation [12, 18]

Disease associations

Inflammation [2, 13]Cardiovascular disease [2, 12, 18]Cancer [11, 13, 18, 20]Neurodegenerative disease [11, 14, 19]Fibrosis [2, 4, 6, 7]Diabetes [2, 3, 19]

Safety considerations

Isoform selectivity [12, 16]Interference with physiological ROS signaling [12, 16]Potential for off-target toxicity [13]

Interacting drugs

Setanaxib (GKT137831) [2, 4, 6]

5 more in the full profile.

Biomarkers

Reactive oxygen species (ROS) levels [2, 13]NOX1 mRNA expression [11]NOX1 protein expression [11]8-isoprostane [2]Urine albumin-to-creatinine ratio (ACR) [2, 3]

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