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NAV2 antisense RNA 3 (NAV2-AS3) is a long non-coding RNA gene located on human chromosome 11 (chr11:19978699-19981337, hg38) and is transcribed from the opposite strand of the NAV2 coding gene[7][1]. As an antisense lncRNA, NAV2-AS3 is classified as a non-protein coding gene whose transcript is presumed to regulate the expression of its sense partner or other genes by RNA–RNA interaction, transcriptional regulation, or epigenetic mechanisms[3][4]. While NAV2 antisense RNAs as a class are increasingly implicated in biological regulation and disease contexts, no direct experimentally established roles, disease associations, interacting drugs, or safety concerns have been reported specifically for NAV2-AS3 in current resources. This distinguishes NAV2-AS3 from closely related antisense RNAs (e.g., NAV2-AS2, which has documented function in atherosclerosis[2]) and aligns with the general understanding that lncRNA functions are often tissue- and context-specific, with high regulatory diversity and frequently unresolved biological roles[3][4][6].
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