NBPF member 21, pseudogene (NBPF21P)

NBPF21P is a pseudogene of the neuroblastoma breakpoint family (NBPF), located at chromosome 3p22.2. Unlike most NBPF genes, which may have protein-coding capacity and possible biological or disease roles[1][2], NBPF21P is annotated as a pseudogene and is thus not considered a therapeutic target nor does it produce a functional protein. The NBPF gene family is noted for its paralogs and contains the NBPF/DUF1220 repeat domains, which have roles in human brain evolution and disease; however, NBPF21P, as a pseudogene, does not actively contribute to known biological functions or disease mechanisms[2][3]. There is no evidence NBPF21P is a receptor, enzyme, transporter, or therapeutic target, nor are there documented drugs, mechanism of action, biomarker utility, or safety information directly associated with it[2][3]. NBPF21P’s annotation as a pseudogene means it does not encode a functional protein and is not an active molecular target in therapeutic settings. Some confusion may arise due to the large number of NBPF family members, many of which are protein-coding genes implicated in neuroblastoma and other diseases, but NBPF21P is specifically classified as a pseudogene, and its biological or clinical relevance is null[2][3].

Other names

neuroblastoma breakpoint family member 21, pseudogeneNBPF21P