Necdin, MAGE family member (NDN)

Necdin, encoded by the **NDN** gene, is a member of the melanoma antigen (MAGE) protein family, located in the Prader-Willi syndrome (PWS) chromosomal region 15q11–q13, and expressed exclusively from the paternal allele due to genomic imprinting[1][2][4][5]. Necdin is primarily expressed in postmitotic neurons and regulates neuronal differentiation, promotes cell survival, and suppresses both cellular proliferation and apoptosis[1][2][3][4][6]. It functions as a transcription factor, binding specific DNA sequences and modulating transcriptional activity, and interacts with regulatory proteins such as E2F1, p53, neurotrophin receptors, and others, integrating complex networks governing neuronal vitality[3][4]. Loss of necdin expression is implicated in Prader-Willi syndrome and neurodevelopmental abnormalities, with reduced expression also associated with increased proliferation and metastasis in various cancers, indicating a tumor suppressor role[2][3][4]. No currently approved drugs target necdin directly, and there are no established safety issues or direct pharmacological interventions related to this protein.

Other names

NecdinNDNHsT16328PWCRPrader-Willi syndrome chromosome regionnecdin homolognecdin, melanoma antigen (MAGE) family membernecdin-like protein

Not applicable, as no direct drug targeting reported