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Neisseria meningitidis Capsular Polysaccharides (Serogroups A, C, Y, W-135) (Nm Polysaccharides (A, C, Y, W-135))
- Target
- Nm Polysaccharides (A, C, Y, W-135)
- Molecular classification
- Polysaccharide, Carbohydrate, Bacterial surface antigen
01
Overview
Neisseria meningitidis capsular polysaccharides are surface carbohydrates that define the serogroup of the bacteria and serve as a major virulence factor by inhibiting phagocytosis and complement-mediated killing. Serogroups A, C, Y, and W-135 are commonly associated with invasive disease. The capsular polysaccharides from these serogroups are used in quadrivalent vaccines to induce protective immunity.
- Other names
- N. meningitidis capsule AN. meningitidis capsule CN. meningitidis capsule YN. meningitidis capsule W-135Meningococcal polysaccharide AMeningococcal polysaccharide CMeningococcal polysaccharide YMeningococcal polysaccharide W-135
02
Mechanism of action
Induction of antibodies against capsular polysaccharides, leading to complement-mediated killing and opsonization of N. meningitidis.
03
Biological functions
Immune evasionAnti-phagocytosisVirulence factorCapsule formation
04
Disease associations
MeningitisSepticemiaInfection
05
Safety considerations
Injection site reactionsFeverAllergic reactionsGuillain-Barré syndrome (rare)
06
Interacting drugs
NmVac4-A/C/Y/W‐135
2 more in the full profile.
07
Biomarkers
Antibody titers against serogroups A, C, Y, W-135Opsonophagocytic activity (OPA) assay
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