Neurite extension and migration factor (NEXMIF) (NEXMIF)

Neurite extension and migration factor (NEXMIF), also known as KIAA2022, is a nuclear protein that plays a pivotal role in the development of the mammalian brain (UniProt: Q5SY16). It is highly expressed during early neurogenesis and is involved in regulating neuronal migration, neurite outgrowth, and the establishment of synaptic connections (NCBI Gene: 340533). Mutations in the NEXMIF gene are a primary cause of X-linked intellectual disability-98 (XLID98), which is frequently associated with epilepsy, autism spectrum disorder, and microcephaly (OMIM: 300523). While NEXMIF is not currently targeted by any approved small-molecule or biologic drugs, it is an active area of research for genetic-based therapies such as gene replacement or antisense oligonucleotides (PubMed: 30104644). The protein likely functions as a transcriptional regulator, and its loss of function disrupts the molecular pathways necessary for normal cognitive development. Because of its critical role in neural architecture, any therapeutic intervention must carefully manage protein levels to avoid potential neurotoxicity associated with overexpression. Research into NEXMIF continues to clarify its interaction partners and the specific gene networks it regulates during cortical development. As a dosage-sensitive gene, it represents a challenging but high-potential target for precision medicine in neurodevelopmental disorders.

Other names

KIAA2022KIDLIAX-linked intellectual disability-associated proteinXLID98

None currently available