Neuroblastoma-amplified gene protein (NBAS) (NBAS)

Neuroblastoma-amplified gene protein (NBAS) is a large, highly conserved peripheral membrane protein and a subunit of the NRZ tethering complex, which bridges SNARE complexes and coordinates Golgi-to-endoplasmic reticulum (ER) retrograde transport. NBAS is essential for vesicle tethering, SNARE assembly, and cellular homeostasis. Mutations in the NBAS gene cause diverse multisystem disorders, most notably infantile liver failure syndrome and immunodeficiency. NBAS is also implicated in neuroblastoma due to frequent gene amplification. Further, NBAS is involved in cell cycle checks, autophagy, glycosylation, and the nonsense-mediated mRNA decay pathway. Current drug discovery efforts focus on identifying ligands for NBAS and exploring its druggability, but no direct therapeutic agents are yet clinically validated[1][2][3][4][6].

Other names

Neuroblastoma-amplified sequenceNAGILFS2SOPHNBAS subunit of NRZ tethering complexNBAS_HUMANA2RRP1O95790Q2VPJ7Q53TK6Q86V39Q8NFY8Q9Y3W5

Not available; no clinically approved drugs act directly on NBAS. Most mechanism data relates to its molecular roles in vesicle tethering and SNARE complex regulation[1][3].