Neuropeptide Y (gene) (NPY)

The neuropeptide Y gene encodes neuropeptide Y, a 36-amino acid peptide neurotransmitter widely expressed in the central and peripheral nervous systems. NPY plays key roles in the regulation of feeding behavior, energy homeostasis, neuroendocrine secretion, and stress responses[1][2][3][4]. Its expression is tightly regulated by physiological and environmental factors, such as fasting, stress, and hormonal signals (e.g., leptin, nerve growth factor)[2][3][5]. Downregulation of NPY gene expression is a biological process relevant to appetite suppression and obesity therapeutics[3].

Other names

NPYPro-neuropeptide YPro-NPY

For drugs targeting NPY pathways: receptor antagonism (Y1, Y2, Y5), antisense inhibition (experimental), gene silencing (experimental/therapeutic RNAi approaches)