Neurotrophic factor release (by mesenchymal stem cells)

Neurotrophic factor release supporting nerve repair/regeneration by mesenchymal stem cells refers to the process by which MSCs secrete a combination of growth factors, cytokines, and neurotrophins—including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), and others—that promote neuronal survival, axonal outgrowth, remyelination, and functional recovery after nerve injury. This secretion is largely paracrine, modulating the immune environment, supporting angiogenesis, and reducing cell death, and is considered the primary mechanism by which MSCs exert neuroregenerative effects. Currently, clinical translation is limited by safety, efficacy variability, and incomplete mechanistic understanding.

Other names

MSC-mediated neurotrophic factor secretionMSC secretome (neurotrophic component)Paracrine support for nerve regeneration by MSCs

Paracrine secretion of neurotrophic factors (NGF, BDNF, GDNF, CNTF, etc.) supporting neuronal survival and axonal regeneration Immunomodulation (secretion of anti-inflammatory cytokines and growth factors) Enhancement of angiogenesis via released factors (VEGF, HGF, IGF) Inhibition of scar tissue formation