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Target intelligence / Profile preview
Neutral Amino Acid Transporter B(0) (ASCT2)
- Target
- ASCT2
- Molecular classification
- Transporter, SLC1 family, Secondary transporter
01
Overview
ASCT2 (SLC1A5) is a sodium-dependent antiporter responsible for the uptake and exchange of small neutral amino acids, with a preference for glutamine. It is highly expressed in proliferative tissues and cancer cells, where it plays a key role in glutamine metabolism and mTORC1 signaling. ASCT2 serves as a receptor for certain retroviruses and is considered a potential target for anticancer drug development.
- Other names
- SLC1A5Alanine, Serine, Cysteine Transporter 2
02
Mechanism of action
Inhibition of amino acid transport (glutamine)
03
Biological functions
Amino acid transportGlutamine transportNeutral amino acid exchangemTORC1 regulationCellular amino acid pool harmonization
04
Disease associations
CancerInfection
05
Safety considerations
Potential for off-target effects due to broad tissue expressionDisruption of normal amino acid homeostasis
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