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Target intelligence / Profile preview
NIN1 (RPN12) binding protein 1 homolog (NOB1)
- Target
- NOB1
- Molecular classification
- Endonuclease, RNA-binding protein, Ribosome biogenesis factor
01
Overview
NIN1 (RPN12) binding protein 1 homolog (NOB1) is an RNA-binding protein and endoribonuclease required for processing of 20S pre-rRNA precursor during ribosome biogenesis, specifically for the maturation and cleavage of 18S rRNA in the cytoplasm and formation of the 40S ribosomal subunit in eukaryotes. It may also play a role in mRNA degradation. NOB1 is not well-characterized as a drug target or clinical biomarker. It is associated with ribosome assembly pathways and related to disease mechanisms in Diamond-Blackfan anemia, but generally not regarded as a direct therapeutic target.
- Other names
- RNA-binding protein NOB1ART4NOB1PPSMD8BP1MSTP158MST158Phosphorylation regulatory protein HP-10Protein ART-4Nin one binding proteinNIN1/PSMD8 binding protein 1 homologPSMD8 binding protein 1Adenocarcinoma antigen recognized by T lymphocytes 4
02
Biological functions
Pre-rRNA processingBiogenesis of 40S ribosomal subunitsmRNA degradation (probable)Metal ion binding
03
Disease associations
Diamond-Blackfan anemiaPotential involvement in cancer (as a processed antigen, but little evidence for major disease associations currently)
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