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Nitric oxide synthase, endothelial (eNOS)
- Target
- eNOS
- Molecular classification
- Enzyme, Nitric Oxide Synthase
01
Overview
Endothelial nitric oxide synthase (eNOS), also known as NOS3, is an enzyme primarily found in vascular endothelial cells that catalyzes the production of nitric oxide (NO) from L-arginine. NO is a crucial signaling molecule involved in vasodilation, inhibition of platelet aggregation, and maintenance of vascular homeostasis. eNOS dysfunction, often due to decreased expression/activity, cofactor deficiency, or excessive oxidative stress, contributes to the pathogenesis of cardiovascular diseases such as hypertension, atherosclerosis, diabetes mellitus, and heart failure.
- Other names
- NOS3
02
Mechanism of action
Enhances nitric oxide production, reduces oxidative stress
03
Biological functions
VasodilationRegulation of vascular toneInhibition of platelet aggregationModulation of blood flowAnti-inflammatoryImmune regulation
04
Disease associations
HypertensionAtherosclerosisDiabetes MellitusHeart FailureCardiovascular disease
05
Safety considerations
eNOS uncoupling leading to superoxide productionPotential for increased oxidative stress if BH4 levels are insufficient
06
Interacting drugs
BH4 (Tetrahydrobiopterin)
2 more in the full profile.
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