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Nitric Oxide Synthase, Inducible (iNOS)
- Target
- iNOS
- Molecular classification
- Enzyme, Nitric Oxide Synthase
01
Overview
Inducible nitric oxide synthase (iNOS), also known as NOS2, is an enzyme responsible for the high-output production of nitric oxide (NO) in response to inflammatory stimuli. Unlike other isoforms of nitric oxide synthase, iNOS is not constitutively expressed but is induced primarily by cytokines and bacterial products. The enzyme plays a key role in immune defense mechanisms and inflammation. Overexpression or dysregulation of iNOS has been implicated in various diseases, including sepsis, osteoarthritis, cancer, and chronic kidney disease. It is considered a therapeutic target for selective inhibition strategies.
- Other names
- NOS2Peptidyl-cysteine S-nitrosylase NOS2Nitric oxide synthase, inducibleNOS2ANOS type IIInducible NO synthaseHepatocyte NOSHEP-NOS
02
Mechanism of action
Selective inhibition strategies
03
Biological functions
Immune responseVasodilationCytotoxicityInflammationS-nitrosylation
04
Disease associations
SepsisOsteoarthritisCancerChronic Kidney DiseaseInfection
05
Safety considerations
Overexpression contributes to oxidative stressExcessive NO productionPotential for DNA damageAberrant cell signaling
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