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Nitric oxide synthase, neuronal isoform (nNOS)
- Target
- nNOS
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Neuronal nitric oxide synthase (nNOS) is one of three major isoforms of nitric oxide synthase (NOS), the enzyme family responsible for synthesizing nitric oxide (NO) from L-arginine. nNOS is constitutively expressed, primarily in neurons throughout the central and peripheral nervous systems, but also found in skeletal muscle and some other tissues. It catalyzes the conversion of L-arginine to NO and L-citrulline and is involved in synaptic plasticity, long-term potentiation, learning, and memory formation. Overproduction or dysregulation of nNOS-derived NO has been implicated in several disease states, making it a therapeutic target.
- Other names
- NOS1Neuronal nitric oxide synthase
02
Mechanism of action
Selective inhibition of nNOS
03
Biological functions
NO synthesisNeurotransmissionNeuroplasticityRegulation of cardiac functionRegulation of smooth muscle function
04
Disease associations
Neurodegenerative disordersNeuropathic painCardiac arrhythmiasErectile dysfunction
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