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Nitric oxide synthase 3, endothelial cell type (NOS3)
- Target
- NOS3
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Nitric oxide synthase 3 (NOS3), also known as endothelial NOS (eNOS), is an enzyme primarily expressed in vascular endothelial cells. It produces nitric oxide (NO) from L-arginine, a key signaling molecule that regulates vascular tone, blood pressure, platelet aggregation, and leukocyte adhesion. eNOS dysfunction is implicated in various cardiovascular diseases.
- Other names
- eNOSEC-NOScNOSConstitutive NOSNOS type III
02
Mechanism of action
L-arginine + NADPH + O2 -> NO + L-citrulline
03
Biological functions
Vascular smooth muscle relaxationRegulation of vascular toneRegulation of blood pressureInhibition of platelet aggregationInhibition of leukocyte adhesionModulation of cellular proliferationAngiogenesisNitric oxide production
04
Disease associations
HypertensionAtherosclerosisEndothelial dysfunctionCardiovascular diseasePulmonary hypertension
05
Safety considerations
eNOS uncoupling can lead to superoxide anion productioneNOS uncoupling can lead to oxidative stresseNOS uncoupling can lead to cardiovascular dysfunction
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