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NOD-, LRR-, and pyrin domain-containing protein 3
- Molecular classification
- Nod-like receptor, Pattern recognition receptor
01
Overview
NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) is a key intracellular sensor protein involved in the innate immune response. Upon activation by PAMPs or DAMPs, it assembles into the NLRP3 inflammasome, leading to caspase-1 activation and the release of pro-inflammatory cytokines IL-1β and IL-18, ultimately resulting in inflammation and pyroptosis. Dysregulation of NLRP3 can lead to autoinflammatory diseases.
- Other names
- NLRP3Cryopyrin
02
Mechanism of action
NLRP3 inflammasome inhibition
03
Biological functions
Inflammasome assemblyCaspase-1 activationIL-1β maturationIL-18 maturationImmune response
04
Disease associations
Autoinflammatory diseasesCryopyrin-associated periodic syndromes (CAPS)Inflammation
05
Safety considerations
Potential for immunosuppressionRisk of infection
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