Nontypeable Haemophilus influenzae Protein D, Protein E, and PilA, and Moraxella catarrhalis Ubiquitous surface protein A2 (NTHi-Mcat Vaccine Antigen Complex)

This target complex consists of four highly conserved surface proteins derived from two major respiratory pathogens: Nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat). Protein D is a highly conserved 42-kDa surface lipoprotein of NTHi that functions as a glycerophosphodiester phosphodiesterase, while Protein E and PilA are involved in adhesion to respiratory epithelial cells and biofilm formation. The Moraxella catarrhalis component, Ubiquitous surface protein A2 (UspA2), is a multifunctional trimeric autotransporter adhesin that plays a critical role in resisting complement-mediated killing and adhering to the extracellular matrix. Together, these proteins serve as the antigenic basis for investigational vaccines designed to prevent acute exacerbations in patients with chronic obstructive pulmonary disease (COPD). By targeting these specific adhesins and virulence factors, the resulting immune response aims to reduce bacterial colonization and the subsequent inflammatory cascade that drives respiratory decline in vulnerable populations.

Other names

NTHi-Mcat antigensProtein D / Protein E / PilA / UspA2GSK3228836A (related vaccine candidate)10-valent pneumococcal conjugate vaccine (contains Protein D)NTHi-Mcat COPD vaccine

Induction of specific humoral and cellular immune responses, including the production of neutralizing antibodies that inhibit bacterial adhesion and promote opsonophagocytosis of Nontypeable Haemophilus influenzae and Moraxella catarrhalis.