Norepinephrine (noradrenaline) (NE (commonly in the US); NA (in the UK))

Norepinephrine is an endogenous catecholamine that functions as a neurotransmitter, hormone, and neuromodulator in both the central and peripheral nervous systems[1][3][4][5]. It is a main mediator of the sympathetic "fight-or-flight" response, increasing heart rate, blood pressure, energy mobilization, and alertness[1][2][3][6]. Norepinephrine is synthesized in the locus coeruleus of the brain and released from sympathetic nerve endings, affecting nearly every organ system. It primarily signals through adrenergic (alpha and beta) G protein-coupled receptors[1][2][3][5]. Measurement of norepinephrine content is commonly used in clinical and research contexts to assess sympathetic activity or certain disease states, but the content itself is not a molecular target for drugs—rather, NE exerts its effects by acting on well-defined receptor targets. In summary: "Norepinephrine content" is *not* a canonical molecular target; the precise scientific entities are the molecule "norepinephrine" and its receptors or transporters[1][3][5][6].

Other names

NoradrenalineNANENoradrenalin

Agonism/antagonism of adrenergic receptors (alpha and beta) Inhibition of norepinephrine reuptake (SNRIs, TCAs) Inhibition of norepinephrine degradation (MAO inhibitors)