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Target intelligence / Profile preview
Norovirus Capsid Protein VP1 (GI.1) (VP1)
- Target
- VP1
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
Norovirus capsid protein VP1 is the major structural protein forming the outer shell of noroviruses, including the GI.1 genotype (Norwalk virus). It plays a central role in viral assembly, host cell attachment, immune recognition, and genetic diversity. VP1 self-assembles into an icosahedral capsid and is comprised of Shell (S) and Protruding (P) domains. The P domain is responsible for binding to histo-blood group antigens (HBGAs) on host cells. Variability in the P2 subdomain contributes to immune evasion and strain diversity. VP1 interacts with minor capsid protein VP2 to assist genome encapsidation and regulates viral genome synthesis. It is a target for neutralizing antibodies and vaccine development.
- Other names
- Norwalk virus capsid protein VP1GI.1 VP1
02
Mechanism of action
N/A
03
Biological functions
Capsid formationReceptor bindingImmune evasionGenome encapsidationAssembly regulation
04
Disease associations
Infection
05
Safety considerations
Antigenic variability leading to immune escapePotential for resistance to therapeutic interventions
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