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Target intelligence / Profile preview
Norovirus capsid protein VP1 (GII.4) (VP1 (GII.4))
- Target
- VP1 (GII.4)
- Molecular classification
- Structural protein, Capsid protein
01
Overview
Norovirus capsid protein VP1 is the major structural protein of noroviruses, forming the outer shell (capsid) of the virus. The GII.4 genotype is the most prevalent and epidemiologically significant variant, responsible for the majority of norovirus outbreaks. VP1 self-assembles to form virus-like particles (VLPs) and mediates attachment to host cells via interactions with histo-blood group antigens (HBGAs). GII.4 VP1 exhibits rapid evolution, particularly in surface-exposed regions that interact with host immune responses.
- Other names
- Norovirus major capsid protein VP1GII.4 VP1Norovirus capsid proteinNorovirus VP1
02
Biological functions
Viral capsid formationHost cell attachmentImmune evasionViral entryReceptor binding
03
Disease associations
InfectionGastroenteritis
04
Safety considerations
Antigenic drift leading to vaccine escapePotential for enhanced disease severity with certain variants
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